Cos Lazouras, VP of development on the "Terminator Salvation" video game, told GamePro that Christian Bale will not appear in the new game, but Rose McGowan (who is not in the movie) will.
Lazouras explained that YOU play as John Connor (but not Bale's likeness) and that two main characters from the movie, Blair Williams (Moon Bloodgood) and Barnes (Common), accompany you in the Resistance against the rise of the robots. "[Williams and Barnes] are central characters in the game and feature both the voice and likeness of the actors."
Rose McGowan (Grindhouse) will lend her voice for the Angie Salter character. "Angie Salter, an ex-high school teacher. Angie is on the verge of completely giving up any hope for humanity's survival and is gratingly cynical throughout the game. Her character arc has a profound effect on Connor."
Lazouras said that the game is a prequel to the upcoming "Terminator Salvation" movie, "set in the year 2016," two years before the events of the movie. He also confirmed that the game is set in a post-apocalyptic Los Angeles taking place "several years after the events of Terminator 3."